Genomic ancestry in kidney cancer: Correlations with clinical and molecular features.

ABSTRACT:

Introduction

Genetic ancestry (GA) refers to population hereditary patterns that contribute to phenotypic differences seen among race/ethnicity groups, and differences among GA groups may highlight unique biological determinants that add to our understanding of health care disparities.

Methods

A retrospective review of patients with renal cell carcinoma (RCC) was performed and correlated GA with clinicopathologic, somatic, and germline molecular data. All patients underwent next-generation sequencing of normal and tumor DNA using Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets, and contribution of African (AFR), East Asian (EAS), European (EUR), Native American, and South Asian (SAS) ancestry was inferred through supervised ADMIXTURE. Mole

SUBMITTER: Kotecha RR 

PROVIDER: S-EPMC11220722 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature