In Vivo Ocular Pharmacokinetics and Toxicity of Siponimod in Albino Rabbits.

ABSTRACT: Siponimod is a promising agent for the inhibition of ocular neovascularization in diabetic retinopathy and age-related macular degeneration. Siponimod's development for ophthalmological application is hindered by the limited information available on the drug's solubility, stability, ocular pharmacokinetics (PK), and toxicity in vivo. In this study, we investigated the aqueous stability of siponimod under stress conditions (up to 60 °C) and its degradation behavior in solution. Additionally, siponimod's ocular PK and toxicity were investigated using intravitreal injection of two different doses (either 1300 or 6500 ng) in an albino rabbit model. Siponimod concentration was quantified in the extracted vitreous, and the PK parameters were calculated. The drug half-life after administration of

SUBMITTER: Alshaikh RA 

PROVIDER: S-EPMC11220753 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature