On the Structure, Stability, and Cell Uptake of Nanostructured Lipid Carriers for Drug Delivery.

ABSTRACT: The efficacy of nanostructured lipid carriers (NLC) for drug delivery strongly depends on their stability and cell uptake. Both properties are governed by their compositions and internal structure. To test the effect of the lipid composition of NLC on cell uptake and stability, three kinds of liquid lipids with different degrees of unsaturation are employed. After ensuring homogeneous size distributions, the thermodynamic characteristics, stability, and mixing properties of NLC are characterized. Then the rates and predominant pathways of cell uptake are determined. Although the same surfactant is used in all cases, different uptake rates are observed. This finding contradicts the view that the surface properties of NLC are dominated by the surfactant. Instead, the uptake rates are explain

SUBMITTER: Jeitler R 

PROVIDER: S-EPMC11220792 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature