Towards a dependable data set of structures for L-asparaginase research.

ABSTRACT: The Protein Data Bank (PDB) includes a carefully curated treasury of experimentally derived structural data on biological macromolecules and their various complexes. Such information is fundamental for a multitude of projects that involve large-scale data mining and/or detailed evaluation of individual structures of importance to chemistry, biology and, most of all, to medicine, where it provides the foundation for structure-based drug discovery. However, despite extensive validation mechanisms, it is almost inevitable that among the ∼215 000 entries there will occasionally be suboptimal or incorrect structure models. It is thus vital to apply careful verification procedures to those segments of the PDB that are of direct medicinal interest. Here, such an analysis was carried out for cryst

SUBMITTER: Wlodawer A 

PROVIDER: S-EPMC11220836 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature