The impact of norepinephrine dose reporting heterogeneity on mortality prediction in septic shock patients.

ABSTRACT:

Background

Norepinephrine (NE) is a cornerstone drug in the management of septic shock, with its dose being used clinically as a marker of disease severity and as mortality predictor. However, variations in NE dose reporting either as salt formulations or base molecule may lead to misinterpretation of mortality risks and hinder the process of care.

Methods

We conducted a retrospective analysis of the MIMIC-IV database to assess the impact of NE dose reporting heterogeneity on mortality prediction in a cohort of septic shock patients. NE doses were converted from the base molecule to equivalent salt doses, and their ability to predict 28-day mortality at common severity dose cut-offs was compared.

Results

4086 eligible patients with septic shock were identified, with a

SUBMITTER: Morales S 

PROVIDER: S-EPMC11220947 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature