Disturbed intracellular folate homeostasis impairs autophagic flux and increases hepatocytic lipid accumulation.

ABSTRACT:

Background

Metabolic associated fatty liver disease (MAFLD), a prevalent liver disorder affecting one-third of the global population, encompasses a spectrum ranging from fatty liver to severe hepatic steatosis. Both genetic and lifestyle factors, particularly diet and nutrition, contribute to its etiology. Folate deficiency, a frequently encountered type of malnutrition, has been associated with the pathogenesis of MAFLD and shown to impact lipid deposition. However, the underlying mechanisms of this relationship remain incompletely understood. We investigated the impact of disturbed folate-mediated one-carbon metabolism (OCM) on hepatic lipid metabolism both in vitro using human hepatoma cells and in vivo using transgenic fluorescent zebrafish displaying extent-, stage-, and durat

SUBMITTER: Chi WY 

PROVIDER: S-EPMC11220954 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature