Abnormal platelet parameters in inflammatory bowel disease: a systematic review and meta-analysis.

ABSTRACT:

Background

Platelet dysfunction plays a critical role in the pathogenesis of inflammatory bowel disease (IBD). Despite clinical observations indicating abnormalities in platelet parameters among IBD patients, inconsistencies persist, and these parameters lack standardization for diagnosis or clinical assessment.

Methods

A comprehensive search was conducted in the PubMed, Embase, Web of Science, and Cochrane Library databases for relevant articles published up to December 16th, 2023. A random-effects model was employed to pool the weighted mean difference (WMD) and 95% confidence interval (95% CI) of platelet count (PLT), mean platelet volume (MPV), platelet distribution width (PDW), and plateletcrit (PCT) between IBD patients and healthy controls, and subgroup analyses were

SUBMITTER: Xu C 

PROVIDER: S-EPMC11221001 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature