TonEBP inhibits ciliogenesis by controlling aurora kinase A and regulating centriolar satellite integrity.

ABSTRACT:

Background

Primary cilia on the surface of eukaryotic cells serve as sensory antennas for the reception and transmission in various cell signaling pathways. They are dynamic organelles that rapidly form during differentiation and cell cycle exit. Defects in these organelles cause a group of wide-ranging disorders called ciliopathies. Tonicity-responsive enhancer-binding protein (TonEBP) is a pleiotropic stress protein that mediates various physiological and pathological cellular responses. TonEBP is well-known for its role in adaptation to a hypertonic environment, to which primary cilia have been reported to contribute. Furthermore, TonEBP is involved in a wide variety of other signaling pathways, such as Sonic Hedgehog and WNT signaling, that promote primary ciliogenesis, suggest

SUBMITTER: Chinbold B 

PROVIDER: S-EPMC11221002 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature