Clinical utility of DNA methylation profiling for choroid plexus tumors.

ABSTRACT:

Background

Choroid plexus tumors (CPTs) are rare, potentially aggressive CNS tumors with defined histologic criteria for grading. In recent years, several patients within our practice have demonstrated discordance between the histologic diagnosis and clinical behavior. DNA methylation profiling has emerged as a potential diagnostic adjunct for aiding the clinical approach.

Methods

We reviewed the clinical and pathologic data of all CPTs diagnosed at Boston Children's Hospital from 1995 to 2023. All cases with available material (38/48) underwent DNA methylation profiling at NIH/NCI, and the classifier results were correlated with the WHO histologic grade and patient outcomes. Survival information was analyzed using Kaplan-Meier curves.

Results

There was good correlati

SUBMITTER: Yeo KK 

PROVIDER: S-EPMC11221062 | biostudies-literature | 2024 Jan-Dec

REPOSITORIES: biostudies-literature