Evidence for inflammation in normal-appearing brain regions in patients with growing sporadic vestibular schwannoma: A PET study.

ABSTRACT:

Background

Nonauditory symptoms can be a prominent feature in patients with sporadic vestibular schwannoma (VS), but the cause of these symptoms is unknown. Inflammation is hypothesized to play a key role in the growth and symptomatic presentation of sporadic VS, and in this study, we investigated through translocator protein (TSPO) positron emission tomography (PET) whether inflammation occurred within the "normal appearing" brain of such patients and its association with tumor growth.

Methods

Dynamic PET datasets from 15 patients with sporadic VS (8 static and 7 growing) who had been previously imaged using the TSPO tracer [¹¹C](R)-PK11195 were included. Parametric images of [¹¹C](R)-PK11195 binding potential (BP_ND) and the di

SUBMITTER: Alfaifi B 

PROVIDER: S-EPMC11221070 | biostudies-literature | 2024 Jan-Dec

REPOSITORIES: biostudies-literature