Antiviral activity of luteolin against porcine epidemic diarrhea virus in silico and in vitro.

ABSTRACT:

Background

Porcine epidemic diarrhea virus (PEDV) mainly causes acute and severe porcine epidemic diarrhea (PED), and is highly fatal in neonatal piglets. No reliable therapeutics against the infection exist, which poses a major global health issue for piglets. Luteolin is a flavonoid with anti-viral activity toward several viruses.

Results

We evaluated anti-viral effects of luteolin in PEDV-infected Vero and IPEC-J2 cells, and identified IC₅₀ values of 23.87 µM and 68.5 µM, respectively. And found PEDV internalization, replication and release were significantly reduced upon luteolin treatment. As luteolin could bind to human ACE2 and SARS-CoV-2 main protease (Mpro) to contribute viral entry, we first identified that luteolin shares the same core binding site on p

SUBMITTER: Wang J 

PROVIDER: S-EPMC11221151 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature