SerpinB2 deficiency is associated with delayed mammary tumor development and decreased pro-tumorigenic macrophage polarization.

ABSTRACT: The in vivo functions of SerpinB2 in tumor cells and tumor-associated macrophages (TAMs) during breast cancer development and metastasis remain elusive. SerpinB2-deficient MMTV-PyMT mice (PyMT^SB2-/-) were previously produced to explore the biological roles of SerpinB2 in breast cancer. Compared with MMTV-PyMT wild-type (PyMT^WT) mice, PyMT^SB2-/- mice showed delayed tumor progression and reduced CK8 + tumor cell dissemination to lymph nodes. RNA-Seq data revealed significantly enriched genes associated with inflammatory responses, especially upregulated M1 and downregulated M2 macrophage marker genes in PyMT^SB2-/- tumors. Decreased CD206⁺M2 and increased NOS2⁺M1 markers were detected in the primary tumors and metastatic lymph

SUBMITTER: Piao YJ 

PROVIDER: S-EPMC11221169 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature