Impact of polypharmacy on 3-year mortality in patients with heart failure: a retrospective study.

ABSTRACT:

Background

Guideline-directed medical therapy (GDMT) is important in heart failure management; however, polypharmacy itself may impact heart failure. Although measures against polypharmacy are needed, current discussion on unilateral drug tapering (including the drugs that should be tapered) is insufficient. In this study, we investigated the relationship between the number of prescribed GDMT drugs and prognosis in patients with heart failure.

Methods

In this single-centre retrospective study, 3,146 eligible patients with heart failure were included and divided into four groups based on the median number of prescribed GDMT drugs and the median number of drugs not included in the GDMT (ni-GDMT) at the time of hospital discharge. The definition of GDMT was based on various Jap

SUBMITTER: Hayashi D 

PROVIDER: S-EPMC11221177 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature