KLK7 expression in human tumors: a tissue microarray study on 13,447 tumors.

ABSTRACT:

Background

Kallikrein-related peptidase 7 (KLK7) is a chymotrypsin-like serine protease which is essential for the desquamation of corneocytes and thus plays a pivotal role in maintaining skin homeostasis. In cancer, KLK7 overexpression was suggested to represent a route for metastasis through cleavage of cell junction and extracellular matrix proteins of cancer cells.

Methods

To comprehensively determine KLK7 protein expression in normal and neoplastic tissues, a tissue microarray containing 13,447 samples from 147 different tumor types and subtypes as well as 608 samples of 76 different normal tissue types was analyzed by immunohistochemistry.

Results

KLK7 positivity was found in 64 of 147 tumor categories, including 17 tumor categories with at least one strongly po

SUBMITTER: Kind S 

PROVIDER: S-EPMC11221178 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature