Characterization of the effects of cannabinoid receptor deletion on energy metabolism in female C57BL mice.

ABSTRACT:

Background

Despite the evidence that energy balance is regulated differently in females and that the endocannabinoid system is sexually dimorphic, previous studies on the endocannabinoid system and energy balance predominantly used male models. Here, we characterize the effects of cannabinoid receptor deletion on body weight gain and glucose metabolism in female C57BL mice.

Methods

Female mice lacking the cannabinoid-1 receptor (CB1R^-/-), cannabinoid-2 receptor (CB2R^-/-), or both receptors (CB1R^-/-/CB2R^-/-) and wild-type (WT) mice were fed with a low (LFD; 10% of calories from fat) or high-fat diet (HFD; 45% of calories from fat) for six weeks.

Results

Female WT mice fed with HFD gained significantly more weight than WT mice

SUBMITTER: Sotzen M 

PROVIDER: S-EPMC11221337 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature