Neglected etiologies of prolonged febrile illnesses in tropical and subtropical regions: A systematic review.

ABSTRACT:

Background

Febrile illnesses that persist despite initial treatment are common clinical challenges in (sub)tropical low-resource settings. Our aim is to review infectious etiologies of "prolonged fevers" (persistent febrile illnesses, PFI) and to quantify relative contributions of selected neglected target diseases with limited diagnostic options, often overlooked, causing inadequate antibiotic prescriptions, or requiring prolonged and potentially toxic treatments.

Methods

We performed a systematic review of articles addressing the infectious etiologies of PFI in adults and children in sub-/tropical low- and middle-income countries (LMICs) using the PRISMA guidelines. A list of target diseases, including neglected parasites and zoonotic bacteria (e.g., Leishmania and Brucell

SUBMITTER: Musumeci S 

PROVIDER: S-EPMC11221637 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature