Exploring CYP2D6 polymorphisms and angiotensin receptor blocker response in the Bai hypertensive population.

ABSTRACT:

Objective

The CYP2D6 enzyme is crucial for the metabolism and disposition of a variety of drugs. This study was conducted to examine the relationship between CYP2D6 gene polymorphisms and the response to angiotensin receptor blocker (ARB)-based treatment in patients of Chinese Bai ethnicity with hypertension.

Methods

Seventy-two hypertensive adults from the Chinese Bai ethnic group, exhibiting systolic blood pressure (SBP) ≥ 140 mmHg or diastolic blood pressure (DBP) ≥ 90 mmHg, were recruited. Targeted regional sequencing was utilized to genotype single nucleotide polymorphisms in the CYP2D6 gene, aiming to assess their frequency and to evaluate their influence on the therapeutic efficacy of ARB medications.

Results

Our research identified nine significant CYP2D6 poly

SUBMITTER: Yang C 

PROVIDER: S-EPMC11221794 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature