Bioinformatics and systems biology approaches to identify potential common pathogeneses for sarcopenia and osteoarthritis.

ABSTRACT: Sarcopenia, a geriatric syndrome characterized by progressive loss of muscle mass and strength, and osteoarthritis, a common degenerative joint disease, are both prevalent in elderly individuals. However, the relationship and molecular mechanisms underlying these two diseases have not been fully elucidated. In this study, we screened microarray data from the Gene Expression Omnibus to identify associations between sarcopenia and osteoarthritis. We employed multiple statistical methods and bioinformatics tools to analyze the shared DEGs (differentially expressed genes). Additionally, we identified 8 hub genes through functional enrichment analysis, protein-protein interaction analysis, transcription factor-gene interaction network analysis, and TF-miRNA coregulatory network analysis. We als

SUBMITTER: Yang J 

PROVIDER: S-EPMC11221828 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature