Effects of the Surgical Ligation of the Ureter in Different Locations on the Kidney over Time in the Rat Model.

ABSTRACT:

Purpose

To evaluate the effects of the surgical ligation of the ureter in different locations on the kidney over time in the rat model.

Methods

A total of 155 rats were enrolled and randomly divided into the case (n = 150) and control (n = 5) groups. The case group included three separate groups (fifty rats in each group) that underwent surgical ureteral ligation at the proximal, middle, and distal ureter. The laboratory tests, and tumor necrosis factor α (TNF-α), were measured in groups. The pathological evaluation for glomerular changes, tubular dilation, interstitial fibrosis, and interstitial infiltration of the inflammatory cells following the obstruction was performed (severity of tubular atrophy categorized too mild (+), moderate (++), and

SUBMITTER: Mohammadi A 

PROVIDER: S-EPMC11221982 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature