Expedited loading with intravenous sotalol is safe and feasible-primary results of the Prospective Evaluation Analysis and Kinetics of IV Sotalol (PEAKS) Registry.

ABSTRACT:

Background

Loading of oral sotalol for atrial fibrillation requires 3 days, frequently in the hospital, to achieve steady state. The Food and Drug Administration approved loading with intravenous (IV) sotalol through model-informed development, without patient data.

Objective

We present results of the first multicenter evaluation of this recent labeling for IV sotalol.

Methods

The Prospective Evaluation Analysis and Kinetics of IV Sotalol (PEAKS) Registry was a multicenter observational registry of patients undergoing elective IV sotalol load for atrial arrhythmias. Outcomes, measured from hospital admission until first outpatient follow-up, included adverse arrhythmia events, efficacy, and length of stay.

Results

Of 167 consecutively enrolled patients, 23% wer

SUBMITTER: Steinberg BA 

PROVIDER: S-EPMC11222028 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature