Self-assembling viral histones are evolutionary intermediates between archaeal and eukaryotic nucleosomes.

ABSTRACT: Nucleosomes are DNA-protein complexes composed of histone proteins that form the basis of eukaryotic chromatin. The nucleosome was a key innovation during eukaryotic evolution, but its origin from histone homologues in Archaea remains unclear. Viral histone repeats, consisting of multiple histone paralogues within a single protein, may reflect an intermediate state. Here we examine the diversity of histones encoded by Nucleocytoviricota viruses. We identified 258 histones from 168 viral metagenomes with variable domain configurations including histone singlets, doublets, triplets and quadruplets, the latter comprising the four core histones arranged in series. Viral histone repeats branch phylogenetically between Archaea and eukaryotes and display intermediate functions in Escherichia coli

SUBMITTER: Irwin NAT 

PROVIDER: S-EPMC11222145 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature