Effect modification by statin use status on the association between fine particulate matter (PM2.5) and cardiovascular mortality.

ABSTRACT:

Background

Numerous studies have linked fine particulate matter (PM2.5) to increased cardiovascular mortality. Less is known how the PM2.5-cardiovascular mortality association varies by use of cardiovascular medications. This study sought to quantify effect modification by statin use status on the associations between long-term exposure to PM2.5 and mortality from any cardiovascular cause, coronary heart disease (CHD), and stroke.

Methods

In this nested case-control study, we followed 1.2 million community-dwelling adults aged ≥66 years who lived in Ontario, Canada from 2000 through 2018. Cases were patients who died from the three causes. Each case was individually matched to up to 30 randomly selected controls using incidence density sampling. Conditional logistic regressi

SUBMITTER: Bai L 

PROVIDER: S-EPMC11222296 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature