Impact of smoking on resected lung cancer depends on epidermal growth factor receptor mutation.

ABSTRACT:

Objectives

Smokers comprise the majority of surgical patients with primary lung cancer. Epidermal growth factor receptor (EGFR) mutation-negative status impacts the treatment of recurrence. However, the prognostic impact of cigarette smoking stratified by EGFR mutation status has not been reported. Therefore, we assessed its impact on patients with resected lung cancer.

Methods

We retrospectively analysed 362 consecutive patients who underwent complete resection for stage 1 primary lung cancer at our institution between 2012 and 2021. The EGFR mutation status was evaluated using the real-time polymerase chain reaction. We compared the overall survival (OS) and disease-free survival (DFS) between patients with and without a history of smoking.

Results

The EGFR mutation

SUBMITTER: Sekihara K 

PROVIDER: S-EPMC11222299 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature