⁶⁸Ga-PSMA-11 PET and mpMRI in the diagnosis of initial lymph node staging of prostate cancer: a head-to-head comparative meta-analysis.

ABSTRACT:

Purpose

This meta-analysis evaluates the comparative diagnostic efficacy of ⁶⁸Ga-prostate-specific membrane antigen-11 PET (⁶⁸Ga-PSMA-11 PET) and multiparametric MRI (mpMRI) for the initial lymph node staging of prostate cancer.

Methods

We searched PubMed and Embase databases through October 2023 for studies that provide a head-to-head comparison of ⁶⁸Ga-PSMA-11 PET and mpMRI, using pelvic lymph node dissection as the gold standard. We assessed sensitivity and specificity using the DerSimonian and Laird method, with variance stabilization via the Freeman-Tukey double inverse sine transformation. The quality of included studies was evaluated using the Quality Assessment of Diagnostic Performance Studies (QUADAS-2) tool.

Results

The meta

SUBMITTER: Wang Y 

PROVIDER: S-EPMC11222328 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature