NAD metabolism-related genes provide prognostic value and potential therapeutic insights for acute myeloid leukemia.

ABSTRACT:

Introduction

Acute myeloid leukemia (AML) is an aggressive blood cancer with high heterogeneity and poor prognosis. Although the metabolic reprogramming of nicotinamide adenine dinucleotide (NAD) has been reported to play a pivotal role in the pathogenesis of acute myeloid leukemia (AML), the prognostic value of NAD metabolism and its correlation with the immune microenvironment in AML remains unclear.

Methods

We utilized our large-scale RNA-seq data on 655 patients with AML and the NAD metabolism-related genes to establish a prognostic NAD metabolism score based on the sparse regression analysis. The signature was validated across three independent datasets including a total of 1,215 AML patients. ssGSEA and ESTIMATE algorithms were employed to dissect the tumor immune micr

SUBMITTER: Cao Y 

PROVIDER: S-EPMC11222388 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature