Identification of commensal gut microbiota signatures as predictors of clinical severity and disease progression in multiple sclerosis.

ABSTRACT: Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system and a leading cause of neurological disability in young adults. Clinical presentation and disease course are highly heterogeneous. Typically, disease progression occurs over time and is characterized by the gradual accumulation of disability. The risk of developing MS is driven by complex interactions between genetic and environmental factors, including the gut microbiome. How the commensal gut microbiota impacts disease severity and progression over time remains unknown. In a longitudinal study, disability status and associated clinical features in 58 MS patients were tracked over 4.2 ± 0.98 years, and the baseline fecal gut microbiome was characterized via 16S amplicon sequencing. Progressor status, def

SUBMITTER: Montgomery TL 

PROVIDER: S-EPMC11222390 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature