Dexamethasone treatment influences tendon healing through altered resolution and a direct effect on tendon cells.

ABSTRACT: Inflammation, corticosteroids, and loading all affect tendon healing, with an interaction between them. However, underlying mechanisms behind the effect of corticosteroids and the interaction with loading remain unclear. The aim of this study was to investigate the role of dexamethasone during tendon healing, including specific effects on tendon cells. Rats (n = 36) were randomized to heavy loading or mild loading, the Achilles tendon was transected, and animals were treated with dexamethasone or saline. Gene and protein analyses of the healing tendon were performed for extracellular matrix-, inflammation-, and tendon cell markers. We further tested specific effects of dexamethasone on tendon cells in vitro. Dexamethasone increased mRNA levels of S100A4 and decreased levels of ACTA2/α-SMA,

SUBMITTER: Dietrich-Zagonel F 

PROVIDER: S-EPMC11222440 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature