Undenatured type II collagen protects against collagen-induced arthritis by restoring gut-joint homeostasis and immunity.

ABSTRACT: Oral administration of harmless antigens can induce suppression of reactive immune responses, a process that capitalises on the ability of the gastrointestinal tract to tolerate exposure to food and commensal microbiome without triggering inflammatory responses. Repeating exposure to type II collagen induces oral tolerance and inhibits induction of arthritis, a chronic inflammatory joint condition. Although some mechanisms underlying oral tolerance are described, how dysregulation of gut immune networks impacts on inflammation of distant tissues like the joints is unclear. We used undenatured type II collagen in a prophylactic regime -7.33 mg/kg three times/week- to describe the mechanisms associated with protective oral immune-therapy (OIT) in gut and joint during experimental Collagen-In

SUBMITTER: Pan P 

PROVIDER: S-EPMC11222443 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature