Neuroimaging biomarkers and CSF sTREM2 levels in Alzheimer's disease: a longitudinal study.

ABSTRACT: Understanding the exact pathophysiological mechanisms underlying the involvement of triggering receptor expressed on myeloid cells 2 (TREM2) related microglia activation is crucial for the development of clinical trials targeting microglia activation at different stages of Alzheimer's disease (AD). Given the contradictory findings in the literature, it is imperative to investigate the longitudinal alterations in cerebrospinal fluid (CSF) soluble TREM2 (sTREM2) levels as a marker for microglia activation, and its potential association with AD biomarkers, in order to address the current knowledge gap. In this study, we aimed to assess the longitudinal changes in CSF sTREM2 levels within the framework of the A/T/N classification system for AD biomarkers and to explore potential associations w

SUBMITTER: Nabizadeh F 

PROVIDER: S-EPMC11222555 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature