The causal relationship between rheumatoid arthritis and bronchiectasis: a bidirectional Mendelian randomization study.

ABSTRACT:

Background

Several observational studies suggested an association between rheumatoid arthritis (RA) and bronchiectasis. Nevertheless, the presence of a causal relationship between these conditions is yet to be determined. This study aimed to investigate whether genetically predicted RA is associated with the risk of bronchiectasis and vice versa.

Methods

We obtained RA genome-wide association study (GWAS) data from FinnGen consortium, and bronchiectasis GWAS data from IEU Open GWAS project. Univariate Mendelian randomization (MR) analysis was performed using inverse variance weighted (IVW) estimation as the main method. Furthermore, bidirectional and replication MR analysis, multivariate MR (MVMR), Mediation analysis, and sensitivity analyses were conducted to validate the f

SUBMITTER: Li Y 

PROVIDER: S-EPMC11222563 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature