Causal relationships between height, screen time, physical activity, sleep and myopia: univariable and multivariable Mendelian randomization.

ABSTRACT:

Background

This study aims to investigate the independent causal relation between height, screen time, physical activity, sleep and myopia.

Methods

Instrumental variables (IVs) for exposures and outcome were obtained from the largest publicly available genome-wide association studies (GWAS) databases. First, we performed a bidirectional univariate MR analysis using primarily the inverse variance weighted method (IVW) with height, screen time, physical activity and sleep as the exposure and myopia as the outcome to investigate the causal relationship between exposures and myopia. Sensitivity analysis was used to demonstrate its robustness. Then the multivariable MR (MVMR) and MR-based mediation approach was further used to estimate the mediating effect of potential confounder

SUBMITTER: Liu X 

PROVIDER: S-EPMC11222599 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature