Cost-effectiveness of dostarlimab plus chemotherapy for primary advanced or recurrent endometrial cancer.

ABSTRACT:

Objective

In the double-blind, phase III, placebo-controlled RUBY randomized clinical trial, dostarlimab plus carboplatin-paclitaxel significantly increased survival among patients with primary advanced or recurrent endometrial cancer (EC). We conducted a cost-effectiveness analysis of dostarlimab in combination with chemotherapy in these patients stratified by mismatch repair-deficient (dMMR) and mismatch repair-proficient (pMMR) subgroups from the perspective of a United States payer.

Materials and methods

A Markov model with three states was employed to simulate patients who were administered either dostarlimab in combination with chemotherapy or chemotherapy based on the RUBY trial. Quality-adjusted life-years (QALYs), lifetime costs, and incremental cost-effectiveness r

SUBMITTER: Huo G 

PROVIDER: S-EPMC11222638 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature