Urine Epidermal Growth Factor and Kidney Function Decline in Middle-Aged Adults.

ABSTRACT:

Rationale & objective

The diagnosis and prognostication of chronic kidney disease (CKD) largely rely on glomerular measures that may not reflect tubular damage. We investigated the associations of urine kidney tubule biomarkers with estimated glomerular filtration rate (eGFR) change among middle-aged adults, when chronic diseases typically emerge.

Study design

An observational cohort study.

Setting & participants

A total of 1,145 participants of the Coronary Artery Risk Development in Young Adults (CARDIA) study without CKD, hypertension, or cardiovascular disease at the year 20 visit.

Exposures

Seven different biomarkers of tubular health: urine epidermal growth factor (EGF), alpha-1-microglobulin (α1m), interleukin-18, kidney injury molecule-1, monocyte chemo

SUBMITTER: Postalcioglu M 

PROVIDER: S-EPMC11222796 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature