Chronic Kidney Disease Stage and Cardiovascular and Mortality Events Among Older Adults: The SPRINT Trial.

ABSTRACT:

Rationale & objective

The risk implications of the Kidney Disease: Improving Global Outcomes (KDIGO) chronic kidney disease classification in older adults are controversial. We evaluated the risk of adverse outcomes in this population across categories of estimated glomerular filtration rate (eGFR) and urinary albumin-creatinine ratio (UACR).

Study design

Prospective cohort.

Settings & participants

In total, 2,509 participants aged ≥75 years in the Systolic Blood Pressure Intervention Trial (SPRINT).

Exposure

KDIGO eGFR and UACR categories. We combined KDIGO categories G1 and G2, G3b and G4, as well as A2 and A3.

Outcomes

Primary SPRINT outcome (composite of myocardial infarction, other acute coronary syndromes, stroke, heart failure, or death from cardi

SUBMITTER: Turbay-Caballero V 

PROVIDER: S-EPMC11222801 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature