Structural brain changes associated with cocaine use and digital cognitive behavioral therapy in cocaine use disorder treatment.

ABSTRACT:

Background

Few studies have investigated changes in brain structure and function associated with recovery from cocaine use disorder (CUD), and fewer still have identified brain changes associated with specific CUD treatments, which could inform treatment development and optimization.

Methods

In this longitudinal study, T1-weighted magnetic resonance imaging scans were acquired from 41 methadone-maintained individuals with CUD (15 women) at the beginning of and after 12 weeks of outpatient treatment. As part of a larger randomized controlled trial, these participants were randomly assigned to receive (or not) computer-based training for cognitive behavioral therapy (CBT4CBT), and galantamine (or placebo).

Results

Irrespective of treatment condition, whole-brain voxel-b

SUBMITTER: McCurdy LY 

PROVIDER: S-EPMC11222934 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature