Early Prostate Cancer Deaths Among Men With Higher vs Lower Genetic Risk.

ABSTRACT:

Importance

Prostate cancer, a leading cause of cancer death among men, urgently requires new prevention strategies, which may involve targeting men with an underlying genetic susceptibility.

Objective

To explore differences in risk of early prostate cancer death among men with higher vs lower genetic risk to inform prevention efforts.

Design, setting, and participants

This cohort study used a combined analysis of genotyped men without prostate cancer at inclusion and with lifestyle data in 2 prospective cohort studies in Sweden and the US, the Malmö Diet and Cancer Study (MDCS) and the Health Professionals Follow-Up Study (HPFS), followed up from 1991 to 2019. Data were analyzed between April 2023 and April 2024.

Exposures

Men were categorized according to modi

SUBMITTER: Plym A 

PROVIDER: S-EPMC11222990 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature