Photoswitchable positive allosteric modulators of metabotropic glutamate receptor 4 to improve selectivity.

ABSTRACT: Metabotropic glutamate receptors (mGlu) regulate multiple functions in the nervous systems and are involved in several neurological disorders. However, selectively targeting individual mGlu subtypes with spatiotemporal precision is still an unmet need. Photopharmacology can address this concern through the utilization of photoswitchable compounds such as optogluram, which is a positive allosteric modulator (PAM) of mGlu₄ that enables the precise control of physiological responses using light but does not have an optimal selectivity profile. Optogluram analogs were developed to obtain photoswitchable PAMs of mGlu₄ receptor with an improved selectivity. Among them, optogluram-2 emerged as a photoswitchable ligand for mGlu₄ receptor with activity as both PAM a

SUBMITTER: Panarello S 

PROVIDER: S-EPMC11223089 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature