The clinical impact of estimating low-density lipoprotein cholesterol (LDL-C) using different equations in the general population.

ABSTRACT:

Background

Low-density lipoprotein cholesterol (LDL-C) is associated with atherosclerotic cardiovascular disease (ASCVD). Friedewald, Sampson, and Martin-Hopkins equations are used to calculate LDL-C. This study compares the impact of switching between these equations in a large geographically defined population.

Materials and methods

Data for individuals who had a lipid panel ordered clinically between 2010 and 2019 were included. Comparisons were made across groups using the two-sample t-test or chi-square test as appropriate. Discordances between LDL measures based on clinically actionable thresholds were summarized using contingency tables.

Results

The cohort included 198,166 patients (mean age 54 years, 54% female). The equations perform similarly at the lower ra

SUBMITTER: Lam R 

PROVIDER: S-EPMC11223329 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature