Developmental change of brain volume in Rett syndrome in Taiwan.

ABSTRACT:

Objective

Rett syndrome (RTT) is characterized by neurological regression. This pioneering study investigated the effect of age on brain volume reduction by analyzing magnetic resonance imaging findings in participants with RTT, ranging from toddlers to adults.

Methods

Functional evaluation and neuroimaging were performed. All scans were acquired using a Siemens Tim Trio 3 T scanner with a 32-channel head coil.

Results

The total intracranial volume and cerebral white matter volume significantly increased with age in the control group compared with that in the RTT group (p < 0.05). Cortical gray matter volume reduction in the RTT group continued to increase in bilateral parietal lobes and left occipital lobes (p < 0.05). The differences in cortical gray matter volume b

SUBMITTER: Jan TY 

PROVIDER: S-EPMC11223417 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature