Brainstem control of vocalization and its coordination with respiration.

ABSTRACT: Phonation critically depends on precise controls of laryngeal muscles in coordination with ongoing respiration. However, the neural mechanisms governing these processes remain unclear. We identified excitatory vocalization-specific laryngeal premotor neurons located in the retroambiguus nucleus (RAm^VOC) in adult mice as being both necessary and sufficient for driving vocal cord closure and eliciting mouse ultrasonic vocalizations (USVs). The duration of RAm^VOC activation can determine the lengths of both USV syllables and concurrent expiration periods, with the impact of RAm^VOC activation depending on respiration phases. RAm^VOC neurons receive inhibition from the preBötzinger complex, and inspiration needs override RAm^VOC-mediated voca

SUBMITTER: Park J 

PROVIDER: S-EPMC11223444 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature