Lung Function and Brain MRI Outcomes in the Atherosclerosis Risk in Communities Neurocognitive Study.

ABSTRACT:

Background

Brain imaging studies may provide etiologic insight into observed links between lung function and dementia and stroke.

Objective

We evaluated associations of lung function measures with brain MRI markers of vascular and neurodegenerative disease in the ARIC Neurocognitive Study, as few studies have examined the associations.

Methods

Lung function was measured at participants' midlife in 1990-1992 (mean age = 56±5 years) and later-life in 2011-2013 (mean age = 76±5 years), and brain MRI was performed in 2011-2013. Linear regression models were used to examine the associations of lung function with brain and white matter hyperintensity (WMH) volumes, and logistic regression models were used for cerebral infarcts and microbleeds, adjusting for potential confou

SUBMITTER: Shrestha S 

PROVIDER: S-EPMC11223445 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature