Catalase-Powered Nanobots for Overcoming the Mucus Barrier.

ABSTRACT: Biological barriers present a significant obstacle to treatment, especially when drugs are administered locally to increase their concentrations at the target site while minimizing unintended off-target effects. Among these barriers, mucus presents a challenge, as it serves as a protective layer in the respiratory, urogenital, and gastrointestinal tracts. Its role is to shield the underlying epithelial cells from pathogens and toxic compounds but also impedes the efficient delivery of drugs. Despite the exploration of mucolytic agents to improve drug delivery, overcoming this protective barrier remains a significant hurdle. In our study, we investigate an alternative approach involving the use of catalase-powered nanobots. We use an in vitro model that simulates intestinal mucus sec

SUBMITTER: Serra-Casablancas M 

PROVIDER: S-EPMC11223492 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature