Reduced resting-state functional connectivity between insula and inferior frontal gyrus and superior temporal gyrus in hoarding disorder.

ABSTRACT:

Background

Hoarding disorder (HD) is characterized by cognitive control impairments and abnormal brain activity in the insula and anterior cingulate cortex (ACC) during disposal of personal items or certain executive function tasks. However, whether there are any changes in resting-state functional connectivity of the insula and ACC remains unclear.

Methods

A total of 55 subjects, including 24 patients with HD and 31 healthy controls (HCs), participated in the study. We acquired resting-state functional magnetic resonance imaging data and examined group differences in functional connectivity from the insula and ACC in whole-brain voxels.

Results

In patients with HD, functional connectivity was significantly lower between the right insula and right inferior frontal gyr

SUBMITTER: Kato K 

PROVIDER: S-EPMC11223522 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature