Human CD56⁺CD39⁺ dNK cells support fetal survival through controlling trophoblastic cell fate: immune mechanisms of recurrent early pregnancy loss.

ABSTRACT: Decidual natural killer (dNK) cells are the most abundant immune cells at the maternal-fetal interface during early pregnancy in both mice and humans, and emerging single-cell transcriptomic studies have uncovered various human dNK subsets that are disrupted in patients experiencing recurrent early pregnancy loss (RPL) at early gestational stage, suggesting a connection between abnormal proportions or characteristics of dNK subsets and RPL pathogenesis. However, the functional mechanisms underlying this association remain unclear. Here, we established a mouse model by adoptively transferring human dNK cells into pregnant NOG (NOD/Shi-scid/IL-2Rγ^null) mice, where human dNK cells predominantly homed into the uteri of recipients. Using this model, we observed a strong correl

SUBMITTER: Jia W 

PROVIDER: S-EPMC11223582 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature