Tutorial on Biostatistics: Sample Size and Power Calculation for Ophthalmic Studies With Correlated Binary Eye Outcomes.

ABSTRACT:

Purpose

To describe and demonstrate sample size and power calculation for ophthalmic studies with a binary outcome from one or both eyes.

Methods

We describe sample size and power calculation for four commonly used eye designs: (1) one-eye design or person-design: one eye per subject or outcome is at person-level; (2) paired design: two eyes per subject and two eyes are in different treatment groups; (3) two-eye design: two eyes per subject and both eyes are in the same treatment group; and (4) mixture design: mixture of one eye and two eyes per subject. For each design, we demonstrate sample size and power calculations in real ophthalmic studies.

Results

Using formulas and commercial or free statistical packages including SAS, STATA, R, and PS, we calculated sample s

SUBMITTER: Ying GS 

PROVIDER: S-EPMC11223621 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature