Experimental and numerical investigation of microdialysis probes for ethanol metabolism studies.

ABSTRACT: Microdialysis is an important technique for in vivo sampling of tissue's biochemical composition. Understanding the factors that affect the performance of the microdialysis probes and developing methods for sample analysis are crucial for obtaining reliable results. In this work, we used experimental and numerical procedures to study the performance of microdialysis probes having different configurations, membrane materials and dimensions. For alcohol research, it is important to understand the dynamics of ethanol metabolism, particularly in the brain and in other organs, and to simultaneously measure the concentrations of ethanol and its metabolites - acetaldehyde and acetate. Our work provides a comprehensive characterization of three microdialysis probes, in terms of recovery rat

SUBMITTER: Lee TA 

PROVIDER: S-EPMC11223630 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature