Hepatic and Renal Histotripsy in an Anticoagulated Porcine Model.

ABSTRACT:

Purpose

To determine the risk of mechanical vessel wall damage resulting in hemorrhage during and after hepatic and renal histotripsy in an anticoagulated in vivo porcine model.

Materials and methods

Non-tumor-bearing pigs (n = 8; mean weight, 52.5 kg) were anticoagulated with warfarin (initial dose, 0.08 mg/kg) to a target prothrombin time (PT) of 30%-50% above baseline. A total of 15 histotripsy procedures were performed (kidney: n = 8, 2.0-cm sphere; liver: n = 7, 2.5-cm sphere). Treatments were immediately followed by computed tomography (CT) imaging. Animals were observed for 7 days while continuing anticoagulation, followed by repeat CT and necropsy.

Results

All animals survived to complete the entire protocol with no signs of disability or distress. Three anima

SUBMITTER: Mauch SC 

PROVIDER: S-EPMC11223641 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature