Metabolomic signatures of inflammation and metabolic dysregulation in relation to colorectal cancer risk.

ABSTRACT:

Background

Inflammation and metabolic dysregulation are associated with increased risk of colorectal cancer (CRC); the underlying mechanisms are not fully understood. We characterized metabolomic signatures of inflammation and metabolic dysregulation and evaluated the association of the signatures and individual metabolites with CRC risk.

Methods

Among 684 incident CRC cases and 684 age-matched controls in the Nurses' Health Study (n = 818 women) and Health Professionals Follow-up Study (n = 550 men), we applied reduced rank and elastic net regression to 277 metabolites for markers of inflammation (C-reactive protein, interleukin 6, tumor necrosis factor receptor superfamily member 1B, and growth differentiation factor 15) or metabolic dysregulation (body mass index, waist c

SUBMITTER: Bever AM 

PROVIDER: S-EPMC11223797 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature