Multi-tissue transcriptome-wide association studies identified 235 genes for intrinsic subtypes of breast cancer.

ABSTRACT:

Background

Although genome-wide association studies (GWAS) of breast cancer (BC) identified common variants which differ between intrinsic subtypes, genes through which these variants act to impact BC risk have not been fully established. Transcriptome-wide association studies (TWAS) have identified genes associated with overall BC risk, but subtype-specific differences are largely unknown.

Methods

We performed two multi-tissue TWAS for each BC intrinsic subtype, including an expression-based approach that collated TWAS signals from expression quantitative trait loci (eQTLs) across multiple tissues and a novel splicing-based approach that collated signals from splicing QTLs (sQTLs) across intron clusters and subsequently across tissues. We used summary statistics for five in

SUBMITTER: Li JL 

PROVIDER: S-EPMC11223833 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature