Proscan: a structure-based proline design web server.

ABSTRACT: The ability to control protein conformations and dynamics through structure-based design has been useful in various scenarios, including engineering of viral antigens for vaccines. One effective design strategy is the substitution of residues to proline amino acids, which due to its unique cyclic side chain can favor and rigidify key backbone conformations. To provide the community with a means to readily identify and explore proline designs for target proteins of interest, we developed the Proscan web server. Proscan provides assessment of backbone angles, energetic and deep learning-based favorability scores, and other parameters for proline substitutions at each position of an input structure, along with interactive visualization of backbone angles and candidate substitution sites on st

SUBMITTER: Felbinger N 

PROVIDER: S-EPMC11223860 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature